New Assays and Tools for Predicting Hepatotoxicity

Philadelphia, United States 6 7 June / 2012

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About the trade show

Over the last several years, some pharmaceutical companies have successfully used genome wide assocation (GWA) to find genetic susceptibility loci for hepatoxicity observed in clinical trials. In one case, this approach has lead to a proposal to reintroduce with routine genetic testing a drug that has been withdrawn from worldwide markets due to DILI. Genotyping data from the largest DILI genebanks (the International Severe Adverse Events Consortium and the U.S. based Drug Induced Liver Injury Network) have been recently pooled. GWA analysis of this dataset, which reflects DILI due to over 200 different drugs, is providing fresh insight into mechanisms underlying DILI and should inform the hunt for epigenetic and environmental factors underlying DILI.
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Venue: Loews Philadelphia Hotel
Address: 1200 Market Street , Philadelphia, United States
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