Targeting Parkinson's Disease

Philadelphia, United States 4 June / 2012

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About the trade show

While recent genetic studies have provided evidence for systemic mitochondrial impairment in PD, the first proof-of-concept came years earlier from rotenone-treated rats. The rotenone model of PD accurately reproduces many features of the human disease, including nigrostriatal degeneration and DOPA-responsive behavioral deficits, aggregation of endogenous alpha-synuclein with Lewy pathology, and microglial activation. It also recapitulates the gastrointestinal pathology and functional deficits seen in the human disease. Moreover, epidemiological studies have shown that rotenone is a bona fide risk factor for human PD. As such, the rotenone model may have substantial value for pre-clinical testing.   
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Location

Venue: Loews Philadelphia Hotel
Address: 1200 Market Street , Philadelphia, United States
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