Anti-Inflammatories: Small Molecule Approaches

San Diego, United States 17 18 April / 2012

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About the trade show

Genetic deficiency of Jak3 leads to abrogation of signal transduction through the common gamma chain and thus to immunodeficiency suggesting that specific inhibition of Jak3 kinase may result in immunosuppression. However, Jak1 always cooperates with Jak3 in signalling through gamma chain-containing receptors. We will provide evidence that Jak1 plays a dominant role over Jak3. These data challenge the notion that selective ATP-competitive Jak3 kinase inhibitors will be effective.
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Venue: Hilton San Diego Resort
Address: 1775 East Mission Bay Drive San Diego, CA , United States
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