Drug Discovery Chemistry

San Diego, United States 17 19 April / 2012

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About the trade show

The advancing technology of highthroughput screening is changing the type of molecules found; functional assays have supplanted sterically oriented binding assays and with that change has come an increasing incidence of detection of molecules that affect receptor function in ways different from binding. Since protein function is more physiologically more relevant, this, in turn, is changing the quality of the molecules that pharmacologists and medicinal chemists must deal with in the discovery and development process. These changes involve:

  • The way we screen for new drugs
  • The types of molecules we have to develop as therapeutic agents
  • The way we quantify drug activity for medicinal chemists in lead optimization

This course will deal with these issues and familiarize pharmacologists and chemists with the tools needed to exploit this potentially extremely fruitful area of new drug discovery. The course is designed to answer these questions:

  • What is protein allostery?
  • What makes allosteric molecules unique and how can this contribute to unique therapeutic properties?
  • How can we detect allosterism?
  • How can we quantify allosterism for chemical lead optimization?
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Venue: Hilton San Diego Resort
Address: 1775 East Mission Bay Drive San Diego, CA , United States
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